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The lack of immunogenicity has practical implications: the peptide can be used for extended periods without loss of efficacy due to antibody neutralization, there is minimal risk of allergic or hypersensitivity reactions, and repeated treatment cycles are supported as prior exposure does not sensitize the immune system

A systematic review and meta-analysis in PLOS One (2023) examined multiple human trials and concluded that allulose consumption effectively reduces postprandial (after-meal) blood glucose levels in healthy individuals

The theoretical basis is sound

Of course, the injectable GLP-1 drugs are just mimicking the natural GLP hormone that your own body manufactures

GLP-1 receptor activation in the kidneys also produces a mild natriuretic effect through NHE3 inhibition in the proximal tubule